CAS number:70288-86-7
Ivermectin is white crystalline powder, odorless. It is freely soluble in methanol, ethanol, acetone, ethyl acetate, practically insoluble in water, and slightly hygroscopic. Ivermectin is a semisynthetic macrolide multi-component antibiotic, which mainly contains ivermectin B1 (Bla + B1b) content of not less than 93%, of which Bla content of not less than 85%.
Ivermectin is routinely used to control parasitic worms in the gastrointestinal tract of ruminant animals. These parasites normally enter the animal when it is grazing, pass the bowel, and set and mature in the intestines, after which they produce eggs that leave the animal via its droppings and can infest new pastures. Ivermectin is effective in killing some, but not all, of these parasites.In dogs it is routinely used as prophylaxis against heartworm.
This product has a selective inhibitory effect, by binding to the high affinity of chloride channels with glutamate as the valve in nerve cells and muscle cells of spinless animals, which leads to the increase of permeability of cell membranes to chloride ions, causes hyperpolarization of nerve cells or muscle cells, and causes paralysis or death of parasites. It also interacts with chloride channels of other ligand valves, such as the neurotransmitter g-aminobutyric acid (GABA). The selectivity of this product is because some mammals do not have glutamate-chloride channels in vivo, and avermectin has only low affinity for mammalian ligand-chloride channels. This product cannot penetrate the human blood-brain barrier. Onchocerciasis and strongyloidiasis and hookworm, ascaris, Trichuris trichiura, and Enterobius vermicularis infections.
Ivermectin is a medication used to treat many types of parasite infestations. Ivermectin is used to treat animals diseases caused by roundworms and ectoparasites.
In veterinary medicine, it is used to prevent and treat heartworm and acariasis, among other indications. It can be taken by mouth or applied to the skin for external infestations. Ivermectin is widely used for gastrointestinal nematodes, lungworms, and parasitic arthropods in cattle, sheep, horses, and pigs, intestinal nematodes in dogs, ear mites, Sarcoptes scabiei, heart filariae, and microfilariae, and gastrointestinal nematodes and ectoparasites in poultry.
Preparations: Ivermectin injection1% ,2% ,3.4%, 4%; Ivermectin oral solution 0.08%, 0.8%, 0.2%; Ivermectin premix; Ivermectin bolus; Ivermectin pour-on solution 0.5% ,1% , Ivermectin gel 0.4%
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