Composition Per Gram
Amoxiciline Trihydrate............... 260MG
Collistine............................................1,000.000IU
Description
The combination of amoxycillin and colistin acts additive. Amoxycillin is a semisynthetic broadspectrum penicillin with a bactericidal action against both Gram-positive and Gram-negative bacteria. The spectrum of amoxycillin includes Campylobacter, Clostridium, Corynebacterium, E. coli,Erysipelothrix, Haemophilus, Pasteurella, Salmonella, penicillinase-negative Staphylococcus and Streptococcus, spp. The bactericidal action is due to inhibition of cell wall synthesis.
Amoxicillin is mainly excreted in urine. A major part can also be excreted in bile. Colistin is an antibiotic from the group of polymyxins with a bactericidal action against Gram-negative bacteria like E. coli, Haemophilus and Salmonella. Since colistin is absorbed for a very small part after oral administration only gastrointestinal indications are relevant.
Indications
Gastrointestinal, respiratory and urinary tract infections caused by amoxicillin and colistin sensitive micro-organisms, like Campylobacter, Clostridium, Corynebacterium, E. coli, Erysipelothrix, Haemophilus, Pasteurella, Salmonella, penicillinase negative Staphylococcus and Streptococcus spp. in calves, goats, poultry, sheep and swine.
Contra indications
Hypersensitivity to amoxicillin and/or colistin.
Administration to animals with a seriously impaired renal function.
Concurrent administration of tetracyclines, macrolides and lincosamides.
Administration to animals with an active microbial digestion.
Dosage
For oral administration:
Calves, goats and sheep:
Twice daily 5 g per 100 kg body weight for 3 - 5 days.
Poultry and swine:
1 kg per 1000 - 2000 litres of drinking water for 3 - 5 days.
Note: for pre-ruminant calves, lambs and kids only.
Before adding to the drinking water make a presolution of 1 kg Amoxicol per 20 litres of water with a temperature of 40 °C.
Side effects
Hypersensitivity reactions, renal dysfunction, neurotoxicity and neuromuscular blockade.
Withdrawal times
For meat: 8 days.
Storage
Store in the place below 30ºC,keep dry and cool.
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